Activity of the fluoroquinolone DC-159a in the initial and continuation phases of treatment of murine tuberculosis.
نویسندگان
چکیده
DC-159a is a new fluoroquinolone with more potent in vitro activity than available fluoroquinolones against both drug-susceptible and fluoroquinolone-resistant Mycobacterium tuberculosis. Here, we report that DC-159a displays pharmacokinetics similar to those of moxifloxacin yet is more active than moxifloxacin during both the initial and continuation phases of treatment in a murine model. These results warrant further preclinical evaluation of DC-159a in selected drug combinations against drug-susceptible and fluoroquinolone-resistant tuberculosis.
منابع مشابه
In Vivo Efficacy of DC-159a, a New Generation of Respiratory Quinolone, against Experimental Murine Tuberculosis due to Multi-Drug-Resistant Mycobacterium tuberculosis
N H2 OMe Me 1/2 H2O The concentration and lung/serum ratio of DC-159a in CBA/JNCrlj mice were higher than those of MFLX, LVFX and gemifloxacin, described in Kurosaka et al. (the 46th ICAAC, poster No. F1-0489). As in the case of CBA/JNCrlj mice, DC-159a showed high concentrations in BALB/c mice after oral dosing. Accorded with the promising in vitro activity against M. tuberculosis isolates sho...
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The in vitro activities of DC-159a against seven species of Mycobacterium were compared with moxifloxacin, gatifloxacin, levofloxacin, and rifampin. DC-159a was the most active compound against quinolone-resistant multidrug-resistant M. tuberculosis (MIC(90), 0.5 microg/ml) as well as drug-susceptible isolates (MIC(90), 0.06 microg/ml). The anti-tubercle bacilli activity of DC-159a was 4- to 32...
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BACKGROUND Fluoroquinolones are a class of antibacterial agents used for leprosy treatment. Some new fluoroquinolones have been attracting interest due to their remarkable potency that is reportedly better than that of ofloxacin, the fluoroquinolone currently recommended for treatment of leprosy. For example, DC-159a, a recently developed 8-methoxy fluoroquinolone, has been found to be highly p...
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The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma genitalium, and Ureaplasma species to DC-159a, an investigational fluoroquinolone, in comparison with those to other agents were determined. Macrolides were the most active agents against M. pneumoniae and M. genitalium, whereas clindamycin was most activ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 55 4 شماره
صفحات -
تاریخ انتشار 2011